Gila monsters are venomous lizards, native to the southwestern United States and northwestern Mexico. Recently, a Colorado man succumbed to a bite from a captive Gila monster. Historic data regarding deaths from Gila monster bites are scant and poorly documented. Victims of Gila monster bites commonly report excruciating pain lasting hours to days, accompanied by symptoms such as vomiting, diarrhea, sweating, and even loss of consciousness. There is no antivenom due to the rarity of fatalities, but prompt medical attention is crucial following a bite, involving tetanus vaccination, pain management, and supportive care.